Direct Healthcare Access is a specialized clinical laboratory which provides services defined by over our 35 years of experience in the industry. Our laboratory president, Ellen Hanson, CLT (HHS), MLT (ASCP), is the most experienced laboratory technician available worldwide when it comes to running the kryptopyrrole test. She worked with William J. Walsh, PhD, in the 70’s to validate the kryptopyrrole procedure. This procedure has been used on over 50,000 patients with conditions ranging from autism to AD(H)D to other behavioral and emotional conditions. It is the same procedure we perform today. We are the only laboratory in the U.S.A. that reports both an actual (uncalculated) and a calculated (corrected) kryptopyrrole result. The calculated result compensates for how dilute or concentrated the urine specimen is, providing a more accurate test result. Specimen integrity is everything, and we are very specific with our patient directions and shipping procedures so that we can maintain the highest possible standard of KP testing. Also, we offer complimentary clinical consultations with Albert Mensah, MD, and Judith Bowman, MD, Pfeiffer/Walsh-trained doctors, regarding the test results and their interpretation.

Our laboratory is endorsed by William Walsh PhD, founder of the original Pfeiffer Treatment Center and the president of the Walsh Research Institute.


Medical Doctors, Naturopathic Doctors, Doctors of Osteopathic Medicine ordering testing can receive a complimentary clinical consultation regarding the test results and their interpretation. For CNP’s, N.P.’s, and nutritionalists, complimentary consults must be scheduled with you and your collaborating doctor.

Our Patient Direct Access program was developed so any test we offer can be ordered direct. How does this work? Our doctor will place your order and review your results. However, it does not include an interpretation of the test results. If you need guidance in interpreting your test results, you can order a clinical consultation. Which includes a review of your health history, test results, telephone consultation and a written report of recommendations for supplements.


Practitioners: Contact us at 847-222-9546 or email to set up an account.

Patient Direct: You can call us at 847-222-9546 to process your order or you can order on line at our secure website. Our website check out process is secure and your credit card information is protected.  It is simple, easy and secure.  You can process orders using your HSA card. If you do not want to check out on line please call us at 847-222-9546 so we can process you order.







The following tests are used in the diagnosis of biochemical imbalances


We are the leader in kryptopyrrole urine testing. We have been performing the test for over 25 years. Where we differ from other labs is that we report out to you an actual kryptopyrrole test result and a calculated kryptopyrrole test result. Concentration of urine varies i.e., when you wake up in the morning your first morning urine specimen is very concentrated. As the day goes on the more water you drink the more dilute your urine becomes. The calculated kryptopyrrole result makes a correction for how dilute or concentrated your urine specimen is. Making the test result very accurate and easy to follow. In example, you may have a normal actual kryptopyrrole result but when the calculation is applied your result may be higher.

  • Pyrrole disorder/pyroluria is diagnosed by finding elevated kryptopyrrole in urine.
  • When elevated in urine, it represents a marker for functional deficiencies  of vitamin B6 and zinc.
  • Symptoms include: poor tolerance of physical and emotional stress, poor anger control, frequent mood swings, poor short term memory, reading disorder, morning nausea, absence of dream recall, frequent anger and rages, depression and high anxiety.
  • Supplements should be titrated to the individuals age, body weight, lab results, severity of symptoms and ability to metabolize supplements.
  • Used to make the initial diagnosis and follow-up testing is used to monitor the effectiveness of replacement therapy.
  • Klinghardt, MD, PhD found kryptopyrrole is found in up to 80% of lymes patients and when correctly diagnosed and the recommended substitution of supplements is included in treatment of any chronic illness, outcome can be dramatically improved.

Pyroluria is a genetically determined chemical imbalance involving an abnormality in hemoglobin synthesis. Hemoglobin is the protein that holds iron in the red blood cell. Individuals with this disorder produce too much of a byproduct of hemoglobin synthesis called “kryptopyrrole” (KP) or “hemepyrrole.” Kryptopyrrole has no known function in the body and is excreted in urine.

Kryptopyrrole binds to pyridoxine (vitamin B6) and zinc and makes them unavailable for their important roles as co-factors in enzymes and metabolism. These essential nutrients when bound to kryptopyrrole are removed from the bloodstream and excreted into the urine as pyrroles.   The effect of pyroluria can have a mild, moderate, or severe depending on the severity of the imbalance. Most individuals show symptoms of zinc and/or B6 deficiencies, which include poor stress control, nervousness, anxiety, mood swings, severe inner tension, episodic anger (an explosive temper), poor short-term memory and depression. Most pyrolurics exhibit at least two of these problems. These individuals cannot efficiently create serotonin (a neurotransmitter that reduces anxiety and depression) since vitamin B6 is an important factor in the last step of its synthesis. In addition, these individuals often have frequent infections and are often identified by their inability to tan, poor dream recall, abnormal fat distribution, and sensitivity to light and sound. Classic symptoms of pyrrole disorder include high anxiey, frequent mood swings, poor short term memory, reading disorder, morning nausea, absence of dream recall and frequent anger and rages.

Pyroluria is detected by chemical analysis of abnormal pyroles in urine. The reference ranges for kryptopyrrole are: 0-10 mcg/dl is considered the optimal range. Person exhibiting clinical symptoms with a number of 8 and above may be considered borderline pyroluria. Persons with 10-20 mcg/dl are considered “borderline” pyroluric and may benefit from treatment. Persons with levels above 20 mcg/dl are considered to have pyroluria, especially if symptoms are present.

To make the initial diagnosis, no vitamins or minerals should be taken for two days before the urine is collected (This is to avoid false negative results). The specimen should be handled properly as well – collected and frozen immediately and protected from light.

People with mild-moderate pyroluria usually have a fairly rapid response to treatment if no other chemical imbalances are present. People with severe pyroluria usually require several weeks before progress is seen and improvement may be gradual over 3 – 12 months. Features of pyroluria usually recur within 2 – 4 weeks if the nutritional program is stopped. Persons born with pyrrole disorder may have a lifetime tendency for deficencies of B-6, zinc, and for high oxidative stress. Any source of oxidative stress can elevate urinary pyrrole levels. Many persons have elevated pyrroles resulting from factor such a physical accidents, illnessess, infections, emotional trauma and toxic metals.

Pyroluria is managed in part by restoring vitamin B6 and zinc. The type of replacement therapy is very important as zinc must be provided in an efficiently absorbed form. Vitamin B6 is also available in several forms. Both zinc and B6 supplementation need to be directed by the doctor as too much can be toxic, use of the wrong form will be ineffective, and avoiding competing minerals and supplements may be necessary. Other nutrients may assist in pyroluria include niacinamide, pantothenic acid, manganese, vitamins C and E, omega-6 fatty acids and cysteine.

Because pyrolurics are stress intolerant, they seem to be especially vulnerable to cumulative stress over many days. Pyroluric patients are prone to relapses, especially during illness, injury, or emotional stress.

Much of the information we have about pyroluria is from the work of the late Carl Pfeiffer, M.D. in the 1970’s.

Some references include:  William J.Walsh, PhD: Nutrient Power: Heal Your Biochemistry and Heal Your Brain (Skyhorse Publishing, 2012)

Irving DG: Apparent non-indolic ehrlich-positive substances related to Mental illness. J Neuropsychiat, 1961;2:292-305.

Hoffer A, Mahon M: The presence of unidentified substances in the urine of psychiatric patients. J Neuropsychiat, 1961;2:331-397.

Irvine DG, Bayne W, et al: Identification of kryptopyrrole in human urine and its relationship to psychosis. Nature, 1969;224:811-813.

Pfeiffer CC, Lliev V: Pyrroluria, urinary mauve factor, causes double deficiency of B6 and zinc in schizophrenics. Fed Proc, 1973;32:276.

Jackson JA, Riordan HD, Neathery S: Vitamins, blood lead and urine pyrroles in Down Syndrome patients. Amer Clin Lab, 1990:Jan- Feb:8-9.

Jackson JA, Riordan HD, Neathery S, Riordan N: Urinary pyrroles in health and disease. J Orthomol Med, 1997: 12;2:96-9


Effective “marker” for methylation is whole blood histamine.

Elevated histamine indicates undermethylation. Review of symptoms and medical history can bolster the diagnosis. For example, most undermethylated persons exhibit seasonal allergies,
perfectionism, strong wills, slenderness, OCD tendencies, high libido, depression.

Low histamine indicates overmethylated persons generally exhibit high anxiety, panic disorders, absence of seasonal allergies, presence of food/chemical sensitivities, dry eyes, low perspiration, artistic/music interests/abilities, intolerance to Prozac and other SSRI’s, etc.

Conditions associated with undermethylation: Anorexia, Bulemia, shopping/gambling disorders, depression, schizo-affective disorder, delusions, oppositional-defiant disorder, OCD.

Conditions associated with overmethylation: Anxiety/Panic disorders, anxious depression, hyperactivity, learning disabilities, low motivation, “space cadet” syndrome, paranoid schizophrenia, hallucinations. (Oct 3, 2003)

Most persons with depression, oppositional defiant disorder, OCD, bipolar disorder, or schizophrenia exhibit a genetic abnormality in methylation….. which appears to be central to their illness. Carl Pfeiffer, MD, PhD of Princeton, NJ was a pioneer in this field. (Oct 3, 2003)                                                                                                                                         



Excessive levels are toxic to the body and can interfere with processes compromising the brain’s access to its major source of fuel, leaving the brain starved for energy.

  • Essential trace element.

Copper overloads tend to lower dopamine levels and increase norepinephrine in the brain. Imbalances in these important neurotransmitters have been associated with paranoid schizophrenia, bipolar disorder, postpartum depression, ADHD, autism and violent behavior.

Carl Pfeiffer of Princeton, NJ tested more than 25,000 persons for copper & reported that Cu toxicity was common, but Cu deficiency extremely rare.

Usually, the question is whether there is a Cu overload. The incidence of true Cu deficiency/depletion is very low. (April 14, 2003)


  • Zinc is a trace metal essential to all forms of life.
  • Enhances resistance to stress and helps maintain intellectual function, memory and mood levels.
  • More than 90% of persons diagnosed with depression, behavioral disorder, adhd, autism and schizophrenia exhibit depleted zinc levels.
  • Zinc defiency has been associated with delayed growth, temper control problems, poor immune function, depression, poor wound healing, epilepsy, anxiety, neurodegenerative disorders, hormone imbalances and learning problems.